Eurosurveillance, Volume 15, Issue 33, 19 August 2010

News

Report published on factors contributing to the spread of Campylobacter in the European Union

Eurosurveillance editorial team ( )¹

1.        European Centre for Disease Prevention and Control, Stockholm, Sweden

The European Food Safety Authority (EFSA) recently published a report on factors that may contribute to the spread of Campylobacter in live chickens and chicken carcasses. The findings of the report [1], based on an European Union (EU)-wide survey [2] will provide the basis for further work by scientific experts to investigate further how Campylobacter-contaminated chicken meat affects the levels of human campylobacteriosis. READ MORE:

http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19641

Vetsweb.com - 24 Aug 2010

A good One Health idea for Veterinary Medicine borrowed from human medical research?

Viral inhibitors: an additional tool to control classical swine fever

http://www.vetsweb.com/background/viral-inhibitors-an-additional-tool-to-control-classical-swine-fever-1384.html

The Summer issue of the One Health Newsletter is now posted online.

 http://www.doh.state.fl.us/Environment/medicine/One_Health/OneHealth.html

Emerging Infectious Diseases Journal – U.S. Centers for Disease Control and Prevention

Volume 16, Number 8–August 2010

Conference Summary

One Health Approach to Influenza: Assessment of Critical Issues and Options¹

Thomas F. Powdrill, Terry L. Nipp, and Jennifer L. Rinderknecht
Author affiliation: Texas A&M University, College Station, Texas, USA

A task force of experts on influenza, public health, and animal health met at the conference One Health Approach to Influenza: Assessment of Critical Issues and Options in Washington, DC, on December 1–2, 2009. These experts discussed the role of the One Health approach in preparing for and responding to an influenza pandemic or other emerging zoonotic disease by using pandemic (H1N1) 2009 as a case study. The meeting was convened by the US Department of Homeland Security National Center for Foreign Animal and Zoonotic Disease Defense, and the National Institute of Allergy and Infectious Diseases/National Institutes of Health Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases.

The One Health concept is the realization that human, animal, and environmental health are interrelated. In practice, it is imperative to implement a One Health approach to high-consequence zoonotic diseases. Although pandemic (H1N1) 2009 virus has primarily affected humans (with some documented human-to-animal transmission), the genesis of this circulating human virus involved reassortment of viral genomic segments from human, porcine, and avian influenza virus lineages. The task force focused on 4 topics: 1) epidemiology and surveillance, 2) transmission dynamics, 3) immunobiology and vaccines, and 4) molecular approaches and pathobiology.  READ MORE:

http://www.cdc.gov/eid/content/16/8/e1.htm

“Cooperation between animal and human health sectors is key to the detection, surveillance, and control of emerging disease”: IMED 2007 meeting in Vienna, February 2007.

Eurosurveillance, Volume 11, Issue 51, 21 December 2006

By Larry Madoff, MD

     Editor, ProMED-mail

     Associate Professor of Medicine

     Harvard Medical School

     Boston, MA

http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=3101

"Regrettably, despite this knowledge, and many dramatic recent examples such as Ebola virus, Lyme disease and SARS, the worlds of veterinary medicine and human health, including public health, remain quite separate. Schools and other training institutions, healthcare facilities, NGOs, public health agencies at all administrative levels, professional and scientific organisations, and journals nearly all remain segregated by their interests in either human medical or veterinary medical health. One of the rare examples that consistently deals with both is ProMED-mail..."  August 19, 2010

John (Jack) Woodall, PhD, Director (retd.)
Nucleus for the Investigation of Emerging Infectious Diseases

Institute of Medical Biochemistry

Center for Health Sciences

Federal University

Rio de Janeiro, Brazil

Dr. Woodall, a viral epidemiologist, is a co-founder and associate editor of ProMED-mail, the outbreak early warning system online of the Program for Monitoring Emerging Diseases of the International Society for Infectious Diseases. He became the contents manager/editor of the ProMED-mail section in the Kahn-Kaplan-Monath-Woodall One Health Initiative website http://www.onehealthinitiative.com in February 2009.

PloS Pathogens – Open Access

Citation: Yamada S, Hatta M, Staker BL, Watanabe S, Imai M, et al. (2010) Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus. PLoS Pathog 6(8): e1001034. doi:10.1371/journal.ppat.1001034

Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

http://www.izs.it/vet_italiana/2010/46_2/137.htm

REMINDER:

1^st International One Health Congress February 2011

Victoria, Australia

Registration Now Open and Available online - See Attached Brochure for Details:

http://www.onehealth2011.com/email/index2.htm

Prominent USA One Health Advocates *Laura H. Kahn, MD, MPH, MPP, James H. Steele, DVM, MPH, and Roger K. Mahr, DVM at American Veterinary Medical Association (AVMA) Convention – Atlanta, GA (USA), July 31 – August 3, 2010

ANNOUNCEMENT AND INVITATION - One Health Bangladesh

8^th Annual Scientific Conference of the Chittagong Veterinary and Animal Sciences University (CVASU)

“Networking for Promoting Change Towards One World One Health”

Please see attachment for details

Notable One Health Advocates *Drs. Paul L. Nicoletti and Lisa A. Conti Receive Prestigious Awards at American Veterinary Medical Association (AVMA) Convention – Atlanta, GA (USA), July 31 – August 3, 2010

Paul L. Nicoletti, DVM, MS, Professor emeritus, University of Florida College of Veterinary Medicine received the Karl F. Meyer—James H. Steele Gold Head Cane Award, for advancing human health through veterinary epidemiology and public health at the 147^th AVMA annual convention in Atlanta, GA (USA).  Dr. Nicoletti was credited for contributing to the control of brucellosis working for the U.S. Department of Agriculture and United Nations as well as the University of Florida.  

Lisa A. Conti, DVM, MPH, Director, Florida Department of Health’s Division of Environmental Health received the AVMA Public Service Award.  Dr. Conti was noted for working with various groups in Florida to protect the public from diseases mediated through environmental processes and serving as Florida's state public health veterinarian and teaching pathobiology at the University of Florida's College of Veterinary Medicine.  She was also awarded an honorary Diploma from the American Veterinary Epidemiology Society (AVES).  The Diploma is for “Distinguished Service and Contribution to the progress of public health.  Her efforts and vision, compassion and understanding, desire and energy, have advanced Veterinary Public Health and research.  Her counsel and advice have been of great value to her country.”

-*Please see attached photo of Drs. Nicoletti and Conti while attending the convention-

Laura H. Kahn, MD, MPH, MPP Receives Honorary Diploma from Thé American Veterinary Epidemiology Society

August 3, 2010 – Atlanta, GA … Dr. Laura H. Kahn was awarded an honorary Diploma from The American Veterinary Epidemiology Society (AVES) at the 147^th American Veterinary Medical Association (AVMA) Annual Convention.

The Diploma is for “Distinguished Service and Contribution to the progress of public health.  Her efforts and vision, compassion and understanding, desire and energy, have advanced Veterinary Public Health and research.  Her counsel and advice have been of great value to her country.”

Dr. Kahn is a prominent international authority and spokesperson for the One Health concept.  She has published numerous articles on the subject and is a widely sought after speaker.  

Please see photo attached: Dr. Kahn is being presented the award by the current President of AVES, George W. Beran, DVM, PhD.  Dr. Beran is a distinguished Professor and zoonotic disease expert at the College of Veterinary Medicine, Iowa State University, Ames, Iowa.

Current One Health Supporters with addresses

SiFy NEWS

Cutting fat, calories ‘can reduce cancer risk in dogs and humans’

July 24, 2010

A new research has revealed that as many as 1 out of 3 cancer deaths in both humans and dogs could be prevented by reducing Omega-6 fatty acids and cutting calories.  READ MORE:

http://sify.com/news/cutting-fat-calories-can-reduce-cancer-risk-in-dogs-and-humans-news-international-khyp4dgefjj.html

U.S. Centers for Disease Control and Prevention (CDC) -  Morbidity and Mortality Report

December 24, 2004 /53(50);1171-1173

Recovery of a Patient from Clinical Rabies --- Wisconsin, 2004

http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5350a1.htm

NEWKERALA.COM, United States

Dogs could help curtail Chagas disease

London, July 13, 2010: A new study says that although dogs are the one of the main carriers of the Chagas disease parasite, they can also help health officials monitor the disease…

http://www.newkerala.com/news/fullnews-145733.html

Food and Agricultural Organization (FAO) of the United Nations

FAO News release - July 26, 2010

http://www.fao.org/news/story/en/item/44327/icode/

Contact:
Erwin Northoff
Media Relations (Rome)
(+39) 06 570 53105
(+39) 348 25 23 616
erwin.northoff@fao.org

Hospitals & Health Networks

One Health

By David Ollier Weber

“The little girl was 2 years old and suffering from a condition rarely encountered in human beings: congenital portosystemic shunt. It's a vascular abnormality that allows blood from the intestines to bypass the liver, thus escaping the filtration process that protects the body against the circulation of toxins. Confronted with this unusual and potentially fatal birth defect, the surgeon duly prepped by searching the medical literature. …”  Read more:

http://www.hhnmag.com/hhnmag_app/jsp/articledisplay.jsp?dcrpath=HHNMAG/Article/data/01JAN2010/100125HHN_Weekly_Weber&domain=HHNMAG

One Health Article Appears in International Innovation Magazine: Research Media Ltd.

http://www.research-europe.com/

The One Health concept was elucidated in a Question and Answer piece that was recently widely distributed online and in a hard copy format through International Innovation magazine, published June 2010.

Laura H. Kahn, MD, MPH, MPP, a prominent member of this One Health Initiative team and a recognized leader in the international One Health movement gave a significant and thoughtful One Health interview: 

Please view the accompanying PDF and see the link below…

http://www.research-europe.com/index.php/2010/07/dr-laura-kahn-on-the-one-health-initiative/

Note: The entire magazine may also be viewed via the following link:

http://www.research-europe.com/magazine/HEALTHCARE/JUN10/pageflip.html

Please register on the Research Media website to gain full access to the entire publication, this is free and quick with your registration being approved within 24 hours.

Thé Jenner Vaccine Foundation Newsletter

Please see PDF View:  Jenner Vaccine Foundation News - Issue 2/May 2010

One Health Initiative Referenced (scroll down to page 7)

http://www.jennervaccinefoundation.org/ 

The Foundation seeks to enhance philanthropic support of vaccinology and is currently evaluating options for enhanced fundraising activities. The Foundation currently supports vaccine research and development through the Jenner Institute. The Foundation Board appoints the Director of the Institute, elects Jenner Investigators (currently numbering 24) and has funded space and facilities for vaccine research and development.

The Foundation actively supports enhanced collaborative interactions between researchers at the Institute for Animal Health working on veterinary vaccines and those at Oxford University developing new vaccines for human use.  The Foundation has also provided support for scientists from the former Edward Jenner Institute for Vaccine Research to continue their work as part of the Jenner Institute. The Foundation draws Trustees from both Oxford University and the Institute for Animal Health (the two Partners in the charity) and has an external chair and three further independent trustees.

Note: The One Health team of the One Health Initiative website considers the Jenner Vaccine Foundation to be a model for the application of One Health principles.  More expeditious and efficacious results for humans and animals are the most likely outcome following the use of such practice. 

“One Health is the collaborative efforts of multiple disciplines working locally, nationally, and globally to attain optimal health for people, animals, plants and our environment.”

“One Health implementation will help protect and/or save untold millions of lives in our generation and for those to come.”

One Health: The Intersection of Humans, Animals and the Environment

Current Issue of the Institute for Laboratory Animal Research (ILAR) Journal Volume 51, Number 3. 

The One Health Initiative website team considers this to be a significant and important contribution to One Health literature.  In toto, it provides more concrete evidence sustaining the premise recognized by many international health scientists that One Health implementation is essential for this generation and for those to come.

Introduction: One Health Perspective (first article) may be viewed by the gracious permission of the ILAR Journal, National Research Council of the National Academies, Washington, D.C. 20001 via issue Managing Editor, Cameron H. Fletcher.

Issue Editor: James G. Fox, DVM, MS, DACLAM

                  Director of the Division of Comparative Medicine and

               Professor in the Division of Biological Engineering at the Massachusetts Institute of Technology

               Cambridge, MA 02139

Entire Issue may be obtained by seeing the following link:

http://www.ilarjournal.com/index.html

The Seattle Times

Lifesaving drugs may be killing health workers

By Carol Smith

InvestigateWest

http://seattletimes.nwsource.com/html/localnews/2012327665_chemo11.html

Nurses, pharmacists and others who handle chemo drugs have been getting sick. Despite multiple studies that indicate the drugs actually may cause cancers, the federal government doesn't require safeguards on the job.

Today Bedbugs are a huge problem for hotels and the tourist industry worldwide.  Perhaps, the answer is indeed a One Health solution?

Please see:

Journal of Economic Entomology and University of Florida-Integrated Pest Management

Household and Structural Insects

Ability of Bed Bug-Detecting Canines to Locate Live Bed Bugs and Viable Bed Bug Eggs

Margie Pfiester, Philip G. Koehler, and Roberto M. Pereira

Department of Entomology, Building 970 Natural Area Drive, University of Florida, Gainesville, FL 32611-0620

J. Eon. Entolmol. 101(4): 1389-1396 (2008)

Learn More about bedbugs at http://ipm.ifas.ufl.edu/community/structural/bed_bug_IPM.shtml

Vetsweb.com - July 2, 2010

Bird flu: New mechanism of circulation and transmission found

An international team of Italy-US scientists reports discovery of a new mechanism of avian influenza virus circulation and transmission in nature. …read more:

http://www.vetsweb.com/news/bird-flu-new-mechanism-of-circulation-and-transmission-found-1244.html

Reported in ProMED:

 http://promedmail.oracle.com/pls/otn/pm?an=20100702.2208

Scientific article Published Plos ONE www.plosone.org June 2010, Volume 5 Issue 6 e11315 by Delogu et. al.

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011315

Urinary schistosomiasis among preschool children in a rural community near Abeokuta, Nigeria

Uwem F Ekpo, Akintunde Laja-Deile, Akinola S Oluwole, Sammy O Sam-Wobo and Chiedu F Mafiana

Parasites and Vectors Online Journal – Open Access

http://www.parasitesandvectors.com/content/3/1/58

Commentary

Altered metabolism in cancer

Jason W Locasale^1,2 and Lewis C Cantley^1,2

¹  Department of Systems Biology, Harvard Medical School, Boston, MA 02215, USA

²  Beth Israel Deaconess Medical Center, Department of Medicine, Division of Signal Transduction, Boston, MA 02215, USA

author email corresponding author email

BMC Biology 2010, 8:88 doi:10.1186/1741-7007-8-88

http://www.biomedcentral.com/1741-7007/8/88

© 2010 Locasale and Cantley; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Wellcome Trust & Wolfson Foundation Funds Establishment of ‘Laboratory of Comparative & Veterinary Virology’ at new Centre for Virus Research at University of Glasgow, Scotland (UK)

Prof. Massimo Palmarini, DVM, PhD, Director of the Medical Research Centre, University of Glasgow Centre for Virus Research notified the One Health Initiative website team today (July 5, 2010)—please see letter posted on Publications page—that Wellcome Trust & Wolfson Foundation has provided funds, £4.8 million, for the establishment of a ‘Laboratory of Comparative & Veterinary Virology’ within the new Centre for Virus Research at University of Glasgow, Scotland (UK). 

Dr. Palmarini is a longtime One Health supporter and has collaborated with members of the One Health Initiative website for nearly four years.  The One Health Initiative team was honored to provide a letter of support that was included in the application for this grant.  Dr. Palmarini will assume directorship of the Centre on August 1, 2010. 

The One Health Initiative team congratulates Dr. Palmarini and his associates and extends our best wishes for success!

U. S. Centers for Disease Control and Prevention -  Morbidity and Mortality Report

West Nile Virus Activity --- United States, 2009

July 2, 2010 / 59(25);769-772

http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5925a1.htm?s_cid=mm5925a1_w

Focusing on neglected zoonoses

Doble L, Fèvre EM

Vet Rec. 2010 May 1;166(18):546-7.

http://www.ncbi.nlm.nih.gov/pubmed/20435977

Abstract

Two tenets at the core of the One Health concept are the belief that human and animal health are irrevocably entwined and that the improvement of both requires close collaboration between the medical and veterinary professions with support from allied disciplines. An ongoing Wellcome Trust-supported project in Western Kenya - the 'People, Animals and their Zoonoses' (PAZ) project - holds the One Health theme at its centre as it endeavours to study neglected zoonoses and provide policy-relevant information about their epidemiology. Veterinarian Lian Doble and the project's leader Eric Fèvre explain why this study is so important

Provided by One Health advocate:

Diane A. Fagen, Librarian

American Veterinary Medical Association (AVMA)

1931 N Meacham Rd

Schaumburg IL 60173

P: 1-800-248-2862 ext 6770

F: 1-847-925-9329

e-mail: dfagen@avma.org

Legislation envisions a Chief Veterinary Officer (CVO) at Department of Homeland Security (USA)

GSN Magazine – Government Security News

Mon, 2010-04-26 03:30 PM

By: Jacob Goodwin

http://www.gsnmagazine.com/article/20591/legislation_envisions_chief_veterinary_officer_dhs

Sri Lanka – Veterinary Epidemiological Bulletin

Volume 3. No. 1.  July-December 2009

Provided by June 26, 2010:

EDITOR,

Ravi Bandara Dissanayake, BVSc, MVSc, Attorney-at-Law

Commissioner for Oaths
National Veterinary Specialist/Sri Lanka

UN-FAO

Lack of association between the occurrence of Crohn’s disease and occupational exposure to dairy and beef cattle herds infected with Micobacterium avium subspecies paratuberculosis

Journal of Dairy Science – Vol. 93 No. 6:2371-2376

American Dairy Science Association, 2010

Provided by:

Charles O. Thoen, DVM, PhD

Department of Veterinary Micobiology and Preventive Medicine

College of Veterinary Medicine

Iowa State University

Ames, Iowa 50014

Emerging Infectious Diseases – U.S. Centers for Disease Control and Prevention (CDC)

Volume 16, Number 6–June 2010 - http://www.cdc.gov/eid/content/16/6/986.htm

Dispatch

Novel Betaherpesvirus in Bats

Shumpei Watanabe,¹ Ken Maeda,¹ Kazuo Suzuki, Naoya Ueda, Koichiro Iha, Satoshi Taniguchi, Hiroshi Shimoda, Kentaro Kato, Yasuhiro Yoshikawa, Shigeru Morikawa, Ichiro Kurane, Hiroomi Akashi, and Tetsuya Mizutani
Author affiliations: The University of Tokyo, Tokyo, Japan (S. Watanabe, N. Ueda, K. Iha, S. Taniguchi, K. Kato, Y. Yoshikawa, H. Akashi); Yamaguchi University, Yamaguchi, Japan (K. Maeda, H. Shimoda); Hikiiwa Park Center, Wakayama, Japan (K. Suzuki); and National Institute of Infectious Diseases, Tokyo (S. Morikawa, I. Kurane, T. Mizutani)

Abstract
Because bats are associated with emerging zoonoses, identification and characterization of novel viruses from bats is needed. Using a modified rapid determination system for viral RNA/DNA sequences, we identified a novel bat betaherpesvirus 2 not detected by herpesvirus consensus PCR. This modified system is useful for detecting unknown viruses.

Emerging Infectious Diseases – U.S. Centers for Disease Control and Prevention (CDC)

Vol. 15, No. 12, December 2009

“I think I could turn and live with animals” –Walt Whitman

Polyxeni Potter

gizmag

Cure for all types of flu could be on the way

By Ben Coxworth

16:53 June 10, 2010

http://www.gizmag.com/cure-for-all-types-of-flu-on-the-way/15380/

·                                 The Sydney Morning Herald

Pet cancer drug goes to human trials

June 13, 2010

http://news.smh.com.au/breaking-news-national/pet-cancer-drug-goes-to-human-trials-20100613-y5ny.html

 Human and Animal Health (USA) – From American Veterinary Medical Association (AVMA) Podcast:

Veterinarians play a prominent role in making sure our food supply is healthy and safe to eat by preventing the spread of foodborne illness among our livestock. Doing so not only keeps the animals healthy, but it also reduces the risk of human exposure to foodborne illnesses.

 In this podcast, W. Ron DeHaven, DVM, MBA, chief executive officer of the AVMA discusses the link between human and animal health and expresses the AVMA’s carefully considered perspectives about the use of antibiotics in food producing animals (i.e. livestock) relative to this practice’s “resistance development” concerns.

 Please listen to Dr. DeHaven by clicking the “MP3” in the following link.

 http://www.avmamedia.org/detail.asp?sid=256&NAME=Human_and_Animal_Health

Factors associated with compliance with community directed treatment with ivermectin for onchocerciasis control in Southwestern Ethiopia

http://www.parasitesandvectors.com/content/3/1/48

Yirga D, Deribe K, Woldemichael K, Wendafrash M, Kassahun W
Parasites & Vectors 2010, 3:48 (2 June 2010)
[Abstract] [Provisional PDF]

Monday, June 7, 2010

The California Aggie

The California Aggie > Campus News > UC Davis observes National Public Health Week

University of California, Davis, CA (USA)  observes National Public Health Week

Professionals discuss topics in societal health

Written by Kyle Sporleder

Aggie Staff Writer

Published on Apr 8, 2010

… [Dr.] Cheryl Scott, program director for the UC Davis School of Veterinary Medicine's Calvin Schwabe One Health Project, suggested collaboration is needed in all fields of health in order to address the concerns of the nation as a whole.

According to Scott, "One Health" is the idea that one must consider factors that affect the health of all organisms.

"One Health is the intersection of human, animal and ecosystem health," Scott said. "It makes sense that since we all live in the same environment, then that environment must be healthy in order for us to be."

Scott wants attention drawn to crises that affect everyone, not just one life or entity, such as infectious diseases, food contamination, drug-resistant bacteria, habitat destruction and air/water quality.

One way to do that, she argues, is to engage students today who will be the workforce we depend on tomorrow.

"We need more smart and passionate people engaged in health issues," Scott said. "They need to be aware that none of us are isolated anymore. What affects one of us will eventually affect all of us. And students entering the health field need to realize that." …

Read the entire article at http://theaggie.org/article/uc-davis-observes-national-public-health-week

A “One Health” Approach to Address Emerging Zoonoses: The HALI Project in Tanzania

Jonna A. K. Mazet, DVM, MPVM, PHD and colleagues describe their work [Plos Medicine] in the Tanzania-based HALI Project, which adopts the “One Health” approach to address emerging zoonoses and that recognizes the interconnectedness of human, animal, and environmental health.

Jonna A. K. Mazet^1*, Deana L. Clifford¹, Peter B. Coppolillo², Anil B. Deolalikar, Jon D. Erickson⁴, Rudovick R. Kazwala⁵3

1 Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, California, United States of America, 2 Wildlife Conservation Society, Bozeman, Montana, United States of America, 3 Department of Economics, University of California, Riverside, California, United States of America, 4 Rubenstein School of Environment and Natural Resources, University of Vermont, Burlington, Vermont, United States of America, 5 Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, Tanzania

http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000190

Structural Basis for Senior Immunity to the Current H1N1 Flu
summary written by Raven Hanna

http://www-ssrl.slac.stanford.edu/research/h1n1_summary.html 

Stanford [University] (USA) Synchrotron Radiation Lightsource

Date Published: May 28, 2010

The above was a lay summary for:

Primary Citation

Xu, R., Ekiert, D.C., Krause, J.C., Hai, R., Crowe, J.E. Jr, Wilson, I.A. Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus. Science 328, 357-360 (2010).

Structural Basis of Pre-existing Immunity to thé 2009 H1N1 Pandemic Influenza Virus

The emergence of the 2009 H1N1 influenza pandemic, also known as the "swine flu", marks the first human flu pandemic in 40 years and has caused significant human infection and mortality globally (1). The emergence of the 2009 H1N1 flu marks the first time that an influenza pandemic was triggered by a virus carrying the same hemagglutinin (HA) subtype as circulating seasonal strains. In contrast, all prior pandemics were caused by the rise of a novel influenza strain with a different hemagglutinin subtype. And unlike seasonal flu that usually affects the elderly most severely, swine flu has been primarily targeting people under the age of 65, implying some age-related pre-existing immunity (2, 3) … … READ MORE at

http://www-ssrl.slac.stanford.edu/research/highlights_archive/h1n1.html.

Parasites & Vectors

5th Symposium on Canine Vector-Borne Diseases

Edited by Chris Arme

This thematic series groups papers presented at the 5th Symposium on Canine Vector-Borne Diseases New York City 12th-15th April 2010

http://www.parasitesandvectors.com/series/CVBD5

Case Study: Veterinarians without Borders-Canada

One health for one world: a compendium of case studies

http://aitoolkit.org/site/DefaultSite/filesystem/documents/OHOW_Compendium_Case_Studies.pdf

This compendium of case studies, prepared by Veterinarians without Borders with support from the Canadian Public Health Agency, promotes that the health of people, animals, and the ecosystem are inextricably woven together. The compendium includes a broad range of disease outbreaks across the globe including avian influenza H5N1 and pandemic influenza H1N1. Each study includes basic information about the clinical disease and the infectious agent associated with it, a description of why the disease is appropriate for one-health approaches, responses and conclusions, and implications for government, business and research policies.

One Health Newsletter Published – May 25, 2010

http://www.doh.state.fl.us/Environment/medicine/One_Health/OneHealth.html

http://www.doh.state.fl.us/Environment/medicine/One_Health/OHNLSpring2010.pdf

Spring Issue, 2010

Volume 3 Issue 2

Centers for Disease Control and Prevention (CDC), Emerging Infectious Diseases—USA

Volume 16, Number 6–June 2010

Favorable Book Review

Human-Animal Medicine: Clinical Approaches to Zoonoses, Toxicants and Other Shared Health Risks

Peter M. Rabinowitz and Lisa A. Conti
Saunders, Maryland Heights, MD, USA, 2009
ISBN: 10-1416068376
Pages: 432; Price: US $99.95

http://www.cdc.gov/eid/content/16/6/1050a.htm

Research

Co-infections with Plasmodium falciparum, Schistosoma mansoni and intestinal helminths among schoolchildren in endemic areas of northwestern Tanzania

Georgia Aquarium Research Center – Spring Newsletter

Please see One Health item of interest:

Dolphins (continued from page 1)

“Of concern is the fact that dolphins and humans are the only species known to be naturally susceptible to infection by Lacazia loboi.  Thus these dolphins may serve as sentinel species for a public health hazard, especially in the Florida coastal region, which is used extensively for recreational purposes.   ……..read more in Newsletter.

Information provided by:

Gregory D. Bossart, VMD, PhD
Senior Vice President and Chief Veterinary Officer
Georgia Aquarium
225 Baker Street, NW
Atlanta, Georgia 30313

and

Adjunct Professor

Department of Pathology

School of Medicine

University of Miami

Miami, Florida
404.581.4304
gbossart@georgiaaquarium.org

United State Department of Agriculture (USDA) – Food Safety and Inspection Service (FSIS) ISSUES GUIDANCE DOCUMENT TO REDUCE E. COLI SHEDDING

Source:  National Meat Association/Lean Trimmings – http://nmaonline.org/pdf/LT5_17_10.pdf

http://nmaonline.org

May 17, 2010
 
FSIS issued a “Guidance Document: for Pre-Harvest Management Controls and Intervention Options for Reducing Escherichia coli O157:H7 Shedding in Cattle, May 2010” on May 10th. This document provides beef slaughter establishments with an informational resource on pre-harvest controls for reducing E. coli O157:H7 and also describes pre-harvest interventions and management practices in various stages of research, and includes a link to references regarding these practices. The OFW memo regarding this document can be viewed in the members’ only section of our website at www.nmaonline.org. This document can be viewed at: www.fsis.usda.gov/PDF/Reducing_Ecoli_Shedding_In_Cattle_0510.pdf.

Role of sand lizards in the ecology of Lyme and other tick-borne diseases in the Netherlands

Parasites & Vectors

http://www.parasitesandvectors.com/content/3/1/42

Mechanism found that may stop E. coli development in cattle

12 May 2010

Microbiologists at UT Southwestern Medical Centre in the US, working with the Department of Agriculture, have identified a potential target in cattle that could be exploited to help prevent outbreaks of food-borne illnesses caused by a nasty strain of Escherichia coli. …

Read more:

http://www.vetsweb.com/news/mechanism-found-that-may-stop-e-coli-development-in-cattle-1113.html

Centers for Disease Control and Prevention (USA)

Morbidity and Mortality Weekly Report (MMWR)

Announcements: Introduction to Public Health Surveillance Course

May 7, 2010 / 59(17);526

http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5917a7.htm

Why you should get to know your local veterinarian

Sue L. Pollock, MD, FRCPC, Craig Stephen, DVM, PhD

Our health is inextricably link­ed to our environment through the air we breathe, the food we eat, and the water we drink. Animals are an integral part of this environment, and our lives are increasingly intertwined with theirs. The recent H1N1 pandemic (swine flu) and an outbreak of E. coli 0157:H7 associated with farm animals in BC have highlighted the importance of this close relationship. 

Almost everyone has some daily interaction with animals, whether through food animals and animal products, wildlife, or household pets. In particular, pet ownership, including exotic animals such as reptiles and birds, is increasingly widespread in Canadian households. It is estimated that more than 50% of Canadian households have at least one cat or dog in their home,[1] which speaks to the importance of pets within the family structure.  …

Read more:  http://www.bcmj.org/why-you-should-get-know-your-local-veterinarian

So What Is the One Health Initiative?

The Human-Animal Bond Blog via The Drake Center:

http://blog.thedrakecenter.com/2010/04/13/so-what-is-the-one-health-initiative/

Animal Instincts

By Claudia Kalb | Newsweek Web Exclusive

Apr 27, 2010

http://www.newsweek.com/id/237036

See - Excellent One Health Brochure

Developed by the U.S. National Park System:

National Park Service Office of Public Health, Wildlife Health, Integrated Pest management, and Risk Management.

One Health movement strong in Bangladesh

See - First Pathobiology eNews

Department of Pathology & Parasitology

Chittagong Veterinary and Animal Sciences University

Chittagong, Bangladesh

Provided by:

Amam Zonaed Sddiki, DVM, MS, PhD (UK), ICGEB Fellow (Italy)
Associate Professor
Department of Pathology and Parasitology
Chittagong Veterinary and Animal Sciences University
Khulshi, Chittagong-4202
Bangladesh

Music Industry News Network

The Alliance for Rabies Control's April 2010 newsletter is now available at:

www.rabiescontrol.net/ARCnewsletter17.pdf

Chicago Breaking News Center…

Field, U. of C. studying how disease jumps from animal to man

April 20, 2010 5:28 PM | UPDATED STORY

Field Museum biologists returned from an African expedition last year with an unusually large collection of 1,100 bird and small mammal specimens, including blood, tissue and stomach content samples.

But what they will do next with those specimens is even more unusual.

They will use them to study how rare diseases - like Ebola, AIDS and SARS - originate in wild animals and then jump to humans with deadly consequences.  …  For more see:

http://www.chicagobreakingnews.com/2010/04/field-u-of-c-studying-how-disease-jumps-from-animal-to-man.html

Shifting from Emergency Response to Prevention of Pandemic Disease Threats at Source

Meeting Report
Chatham House, April 2010

http://www.chathamhouse.org.uk/publications/papers/view/-/id/854/

UN News Centre…

Bird flu, though largely contained, still poses global threat – UN health expert

Avian influenza is still a menace.

16 April 2010 – Although concerted international action has successfully eliminated the deadly H5N1 bird flu virus from poultry in nearly all 63 countries infected by the world outbreak in 2006, it persists in five nations, posing a continuing threat to global animal and human health, a senior United Nations official warned today.  …

See more: http://www.un.org/apps/news/story.asp?NewsID=34387&Cr=&Cr1

Preliminary FoodNet Data on the Incidence of Infection with Pathogens Transmitted Commonly Through Food --- 10 States, 2009

April 16, 2010 / 59(14);418-422

The Foodborne Diseases Active Surveillance Network (FoodNet) of CDC's Emerging Infections Program conducts active, population-based surveillance in 10 U.S. states for all laboratory-confirmed infections with select enteric pathogens transmitted commonly through food (1). This report describes preliminary surveillance data for 2009 and trends in incidence since 1996. In 2009, a total of 17,468 laboratory-confirmed cases of infection were identified. In comparison with the first 3 years of surveillance (1996--1998), sustained declines in the reported incidence of infections caused by Campylobacter, Listeria, Salmonella, Shiga toxin-producing Escherichia coli (STEC) O157, Shigella, and Yersinia were observed. The incidence of Vibrio infection continued to increase. Compared with the preceding 3 years (2006--2008), significant decreases in the reported incidence of Shigella and STEC O157 infections were observed. For most infections, reported incidence was highest among children aged <4 years; the percentage of persons hospitalized and the case fatality rate (CFR) were highest among persons aged ≥50 years. In 2009, the Healthy People 2010 target of ≤1.0 case per 100,000 population for STEC O157 infection (objective 10-1b) was met (2). Further collaborative efforts with regulatory agencies and industry are needed to sustain and extend recent declines and to improve prevention of foodborne infections.

 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5914a2.htm

UN NEWS CENTRE

New UN study urges sustained momentum to tackle human, animal influenza threats

14 April 2010 – While there has been substantial global progress towards pandemic preparedness in recent years, it is vital to maintain that momentum to respond effectively to existing and possible future threats, according to a new study by the United Nations and the World Bank.

“Continued global vigilance for infectious disease outbreaks and pandemics is of critical importance for health security and well-being,” says the report, entitled “Animal and pandemic influenza: a framework for sustaining momentum.”

The report notes that an estimated 75 per cent of new human diseases originate in animals…

For more please see:

http://www.un.org/apps/news/story.asp?NewsID=34368&Cr=pandemic&Cr1

Jenner Vaccine Foundation News

Issue 01/ November 2009

Please see important side bar regarding One Health support on page 5:

“One Health Initiative will be further promoted within the Jenner vaccine Foundation and the Jenner Institute with the appointment of two JENNER FELLOWS in 2010…”

http://www.jennervaccinefoundation.org/JennerNewsletter_web.pdf

One Health Approach to Identify Research Needs in Bovine and Human Babesioses: Workshop Report

Parasites & Vectors 2010, 3:36 (8 April 2010)

[Abstract] [Provisional PDF]

http://www.parasitesandvectors.com/content/pdf/1756-3305-3-36.pdf

Morbidity and Mortality Weekly Report (MMWR) – Centers for Disease Control and Prevention (CDC), U.S.A.

Surveillance for Human West Nile Virus Disease --- United States, 1999--2008

Surveillance Summaries

April 2, 2010 / 59(02);1-17

Nicole P. Lindsey, MS, J. Erin Staples, MD, PhD, Jennifer A. Lehman, Marc Fischer, MD

Division of Vector-Borne Infectious Diseases, National Center for Emerging and Zoonotic Infectious Diseases

Corresponding author: Nicole Lindsey, MS, Division of Vector-Borne Infectious Diseases, CDC, 3150 Rampart Road, Fort Collins, CO 80521. Telephone: 970-266-3595; Fax: 970-266-3568; E-mail: nplindsey@cdc.gov.

http://www.cdc.gov/mmwr/preview/mmwrhtml/ss5902a1.htm

One Health in ACTION!

Scand J Urol Nephrol. 2010 Feb 24. [Epub ahead of print]

Primary bladder phaeochromocytoma diagnosed by a vet.

Oderda M, Michelon F, Appendino M, Gallo M, Senetta R, Pacchioni D, Tizzani A, Gontero P.

Department of Urology, University of Turin, Molinette Hospital, Italy .

Abstract Bladder phaeochromocytomas are rare neuroendocrine neoplasms whose diagnosis can be missed in spite of their rather suggestive presentation. It is mandatory to collect a thorough medical history and to recognize their typical symptoms. This study reports the case of a woman, treated for hypertensive crisis, who was diagnosed with bladder phaeochromocytoma thanks to a vet noting her fainting after micturition.

PMID: 20180653 [PubMed - as supplied by publisher]

 Produced by Rice University (USA) – Center for Technology and learning – http://medmyst.rice.edu

2010 Center for Technology in Teaching and Learning

Provided by:

Kimberly Schuenke, PhD

Associate Director, Center for Biodefense and Emerging Infectious Diseases Program

Administrator Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research

The University of Texas Medical Branch 1.104D Keiller Bldg.

Dept. of Pathology

915 Strand St.

Galveston, TX  77555-0609  (USA)

and

Leslie M. Miller, PhD

Senior Research Scholar

Principal Investigator

MedMyst III: Infectious Disease Materials for Middle School Students

Rice University

6100 Main,

Houston, Texas 77005-1827 (USA)

“Canine Aggression Toward Children” -  a valuable One Health Podcast (USA)

American Veterinary Medical Association MEDIA LIBRARY - http://www.avmamedia.org/default.asp

“Every year, approximately 800,000 people in the United States are bitten by dogs, half of them children. Dr. Ilana Reisner, assistant professor of behavioral medicine at the University of Pennsylvania School of Veterinary Medicine, discusses why children are so disproportionately the victims of dog bites, and how adults can help protect their children through training and education.”

http://www.avmamedia.org/display.asp?sid=78&NAME=Canine_Aggression_Toward_Children

Use of a Reduced (4-Dose) Vaccine Schedule for Postexposure Prophylaxis to Prevent Human Rabies

Recommendations of the Advisory Committee on Immunization Practices

U.S. Centers for Disease Control and Prevention (CDC) – Morbidity and Mortality Report - March 19, 2010 / 59(02);1-9

http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5902a1.htm

United States Animal Health Association (Executive Committee) Approves Support of One Health Initiative

The One Health Initiative website was notified today (March 24, 2010) that The Executive Committee of the United States Animal Health Association (USAHA) recently approved the organization to become an official supporter of the One Health Initiative.  We would appreciate being included in your list of supporters, as well as provide any of our organization’s expertise in animal health to the Initiative.  Attached is a formal letter designating our support [please see letter of support].

Provided by:

Benjamin D. Richey

United States Animal Health Association

Executive Director

4221 Mitchell Ave.

St. Joseph, MO 64507

p: 816.671.1144

f: 816.671.1201

www.usaha.org 

Note: The autonomous pro bono One Health team of Laura H. Kahn, MD, MPH, MPP, Bruce Kaplan, DVM, Thomas P. Monath, MD and Jack Woodall, PhD (managers of the One Health Initiative website) are delighted to learn that the United States Animal Health Association (Executive Committee) has endorsed the One Health concept. 

USAHA, since 1897, has been and continues to be recognized as a premier “non-profit, member-driven, science-based organization devoted to prevention, control and eradication of animal disease in the United States.  USAHA has nearly 1200 members representing state and federal agencies, universities, industry and veterinary organizations and other groups with interest in animal health, disease control, animal welfare, food safety and public health.  USAHA serves as a clearinghouse for new information and methods that can be used in the development of laws, regulations, policy and programs.  Through deliberations of its annual meeting and 32 committees, USAHA works to develop solutions to animal health-related issues.”

USAHA has been added to the One Health Initiative’s website One Health Supporter lists.  Please see http://www.onehealthinitiative.com/supporters.php and http://www.onehealthinitiative.com/publications.php (scroll down).

Capua, I, Cattoli, G. “One Flu for One Health [letter]”.  Emerg Infect Dis. 2010 Apr; [Epub ahead of print]

http://www.cdc.gov/eid/content/16/4/pdfs/09-1593.pdf :

http://www.feedstuffs.com/ME2/dirmod.asp?sid=F4D1A9DFCD974EAD8CD5205E15C1CB42&nm=Breaking+News&type=news&mod=News&mid=A3D60400B4204079A76C4B1B129CB433&tier=3&nid=EB05633A3EC6492C96CC8EF5D812355E

American Veterinary Medical Association (AVMA) tackles veterinary shortage with new program

Vetsweb.com

March 17, 2010

The American Veterinary Medical Association (AVMA), as part of its ongoing effort to boost the number of food animal veterinarians in the US, introduces an educational debt relief program for those veterinarians whose job it is to keep food animals healthy and the food supply safe. ….

http://www.vetsweb.com/news/avma-tackles-veterinary-shortage-with-new-program-967.html

Princeton University (USA) – Program of Science and Global Security

The Biosecurity Seminar Series – Spring 2009

All seminars were held at the Carl Icahn building in Princeton, New Jersey (USA)

Any questions, please contact Laura Kahn, MD, MPH, MPP at lkahn@princeton.edu or 609-258-6763.

http://www.princeton.edu/sgs/seminars/biosecurity/

Notable Example:

March 27, 2009�-�Smallpox Eradication:� What it Taught Us or Did It?"

Speaker:� D.A. Henderson, MD, MPH, Professor, Department of Medicine, School of Medicine; Resident Scholar at the Center for Biosecurity of the University of Pittsburgh Medical Center; former Dean of Johns Hopkins School of Public Health from 1977 to 1990; Directed WHO global smallpox eradication program 1966-1977

link to view videotape of 3/27/09 seminar

FDA mulling restrictions on livestock antibiotics

DesMoinesRegister.com  -  March 10, 2010

http://blogs.desmoinesregister.com/dmr/index.php/2010/03/10/fda-mulling-restrictions-on-livestock-antibiotics/

Science News

Novel Way to Study Human Inflammatory Disease

ScienceDaily (Feb. 28, 2010) — A new University of Colorado at Boulder study shows mice infected with the bacteria salmonella develop clinical signs consistent with a deadly and poorly understood human inflammatory disease, a finding that may lead to new therapies…

http://www.sciencedaily.com/releases/2010/02/100225214812.htm

Dry weather induces outbreaks of human West Nile virus infections

Guiming Wang , Richard B Minnis , Jerrold L Belant and Charles L Wax

BMC Infectious Diseases 2010, 10:38doi:10.1186/1471-2334-10-38 -

http://www.biomedcentral.com/1471-2334/10/38

Chemical causes high contamination levels in Atlantic dolphins

          It brings back old questions about food safety for humans

NEWS Jacksonville.com – March 1, 2010

http://jacksonville.com/news/metro/2010-03-01/story/chemical_causes_high_contamination_levels_in_atlantic_dolphins?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+JacksonvillecomNews+(Jacksonville+Local+News+%E2%80%93+Jacksonville.com+and+The+Florida+Times-Union)

Vol. 7 (2010) / Issue 1 / Book Reviews

Review of Who's In Charge?: Leadership during Epidemics, Bioterror Attacks, and Other Public Health Crises by Laura H. Kahn, MD, MPH, MPP

Robert Lloyd Ditch, Synaptic LLC

Recommended Citation

Ditch, Robert Lloyd (2010) "Review of Who's In Charge?: Leadership during Epidemics, Bioterror Attacks, and Other Public Health Crises," Journal of Homeland Security and Emergency Management: Vol. 7 : Iss. 1, Article 8.

See http://www.bepress.com/jhsem/vol7/iss1/8/

Vector-borne and Zoonotic Diseases

Editor: Stephen Higgs, PhD

Volume 10; Number 1, 2010

Copyright: Mary Ann Liebert, Inc.

Special Issue: Symposium on Ecology of Plague and Its Effects on Wildlife

http://www.liebertonline.com/toc/vbz/10/1

Provided to CDC (USA) ListServe by:

Mira J. Leslie, DVM, MPH

Ministry of Agriculture and Lands

1767 Angus Campbell Road

Abbotsford, BC. V3G 2M3

Ph: (604) 556-3013

Fax: (604) 556-3015

Mira.leslie@gov.bc.ca

One World – One Medicine – One Health

Rev. sci. tech. Off. Int. Epiz, 2009, 28 (2), 481-486

http://www.oie.int/boutique/extrait/04osburn481486.pdf?PHPSESSID=b935473736dc9d8775fe68cb010089e7

Chickens May Provide Clues to Color Vision
Studies of retinal differences in birds could lead to treatments for blindness, researchers say

FRIDAY, Feb. 19 (HealthDay News)

http://www.healthday.com/Article.asp?AID=636123

The Alliance for Rabies Control's February 2010 newsletter is now available at:
www.rabiescontrol.net/ARCnewsletter16.pdf

SALK INSTITUTE For Biological Studies

The mouse with a human liver: a new model for the treatment of liver disease

February 22, 2010

http://www.salk.edu/news/pressrelease_details.php?press_id=408

BIOGRAPHY:

Jack Woodall, PhD

Veterinaria Italiana Journal

2009 - Volume 45 (4), October-December

A quarterly journal devoted to veterinary public health, veterinary science and medicine published by the Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise ‘G. Caporale’ in Teramo, Italy

http://www.izs.it/vet_italiana/2009/45_4/45_4.htm

Humanitarian Resource Institute

HRI:UNArts: Student Loan Debt - Veterinarian shortage plagues rural areas

Provided by Stephen Michael Apatow: Founder, Humanitarian Resource Institute, United Nations Arts Initiative, Pathobiologics International.

http://www.unarts.org/news/asld_2212010.html

VETERINARY Cancer Society NEWS Volume 34, No. 1, Spring 2010

“The Inclusion of Companion Species in Advancing Cancer Therapeutics Through the Concept of One Medicine”

http://www.vetcancersociety.org/Spring_10_VCSN.pdf

Provided February 20, 2010 by:

Ralph C. Richardson, DVM, Dipl ACVIM (Oncology, Internal Med)
Dean, College of Veterinary Medicine
Kansas State University
101 Trotter Hall
Manhattan, KS 66506-5601

CONFERENCE INVITATION

8^th Annual Scientific Conference 

Chittagong Veterinary and Animal Sciences University (CVASU)

April 7-9, 2010

Hotel Agrabad, Chittagong, Bangladesh

 One World-One Health

Wildlife Disease News Digest

http://wdin.blogspot.com/

Wildlife Disease News and Information at your Fingertips.  Brought to you by the National Biological Information Infrastructure (NBII) http://wildlifedisease.nbii.gov/  Wildlife Disease Information Node (WDIN) http://wildlifedisease.nbii.gov/aboutwdin.jsp

“This news service focuses on wildlife diseases, and wildlife morbidity/mortality, especially as they relate to human and ecosystem health.  We work for cover emerging infectious diseases, zoonoses, environmental toxins, population threats, unexplained incidents, die-offs and more.”

Global Zoonoses

http://www.merckvetmanual.com/mvm/servlet/CVMHighLight?file=htm/bc/tzns01.htm&word=zoonoses,table

NOTICE (February 11, 2010):

 The One Health Initiative Website Welcomes …

 Worldwide One Health Submissions for Posting on:

·                         One Health News page

·                         Publications page

·                         Upcoming Events page

Comments and suggestions also appreciated...

 Please send to kkm@onehealthinitiative.com

:: PLEASE TAKE OUR [Short] ONLINE SURVEY ::  SEE OPENING PAGE OF One Health Initiative website.

Thank you!

The autonomous pro bono One Health Initiative website was notified today (February 8, 2010) that the Participatory Epidemiology Network for Animal and Public Health (PENAPH) website www.penaph.net has been launched.   We offer our Congratulations and best wishes!

Provided by:

Saskia Hendrickx, DVM, MSc

International Livestock Research Institute

P.O. Box 30709

Nairobi, 00100 Kenya

Veterinary Practice News

New Cancer Research May Also Benefit Animals

Posted: Tuesday, February 2, 2010, 6:47 p.m., EST

http://www.veterinarypracticenews.com/vet-breaking-news/2010/02/02/new-cancer-research-may-also-benefit-animals.aspx

New literature review REQUEST from “One Health Network”

February 3, 2010

http://www.onehealthnet.be

VetsWeb.com

New insights in pigs spreading Hendra virus to humans

//02 Feb 2010

http://www.vetsweb.com/news/new-insights-in-pigs-spreading-hendra-virus-to-humans-863.html

Parasites & Vectors 2010, 3:5

Francis E G Cox

History of the discovery of the malaria parasites and their vectors

http://www.parasitesandvectors.com/content/pdf/1756-3305-3-5.pdf

Schistosomiasis vaccine discovery using immunomics

Patrick Driguez , Denise L Doolan , Alex Loukas , Philip L Felgner and Donald P McManus

Parasites & Vectors 2010, 3:4doi:10.1186/1756-3305-3-4

http://www.parasitesandvectors.com/content/3/1/4

 http://www.parasitesandvectors.com/content/pdf/1756-3305-3-4.pdf

The recent publication of the Schistosoma japonicum and S. mansoni genomes has expanded greatly the opportunities for post-genomic schistosomiasis vaccine research. Immunomics protein microarrays provide an excellent application of this new schistosome sequence information, having been utilised successfully for vaccine antigen discovery with a range of bacterial and viral pathogens, and malaria. Accordingly, we have designed and manufactured a Schistosoma immunomics protein microarray as a vaccine discovery tool. The microarray protein selection combined previously published data and in silico screening of available sequences for potential immunogens based on protein location, homology to known protective antigens, and high specificity to schistosome species. Following cloning, selected sequences were expressed cell-free and contact-printed onto nitrocellulose microarrays. The reactivity of microarray proteins with antisera from schistosomiasis-exposed/resistant animals or human patients can be measured with labelled secondary antibodies and a laser microarray scanner; highly reactive proteins can be further assessed as putative vaccines. This highly innovative technology has the potential to transform vaccine research for schistosomiasis and other parasitic diseases of humans and animals.

Interesting article intersecting human and animal health:

Volume 16, Number 2–February 2010

Domestic Animals and Epidemiology of Visceral Leishmaniasis, Nepal

Narayan Raj Bhattarai, Gert Van der Auwera, Suman Rijal, Albert Picado, Niko Speybroeck, Basudha Khanal, Simonne De Doncker, Murari Lal Das, Bart Ostyn, Clive Davies,¹ Marc Coosemans, Dirk Berkvens, Marleen Boelaert, and Jean-Claude Dujardin

http://www.cdc.gov/eid/content/16/2/231.htm

Reprinted from Vetsweb.com

http://www.vetsweb.com/news/merial-ibd-summit-the-future-control-of-avian-diseases-852.html

Merial IBD summit: The future control of avian diseases

//27 Jan 2010